Nerve Cells and Synapses: Grade 9 Understanding for IGCSE Biology 2.88 2.89

There is very little in the iGCSE specification about nerve cells and synapses.  This is a shame since neuroscience is going to be one of the massive growth areas in Biology in the 21st century. There is a syllabus point about reflex acs and I draw your attention to this blog post about that:

But in this new post I am going to give you a tiny bit more detail about the types of nerve cells (neurones) that you might encounter, together with an explanation about the most important component of the nervous systems: the chemical synapse.

Neurones are the cells in the nervous system that are adapted to send nerve impulses.  You won’t fully understand what the nerve impulse is until year 13 but it is correct so that it is a temporary electrical event that can be transmitted over large distances within a cell with no loss of signal strength.  The upshot of this is that neurones can be very long indeed…..

There are three basic types of neurone that are grouped according to their function:

Motor neurones (efferent neurones) take nerve impulses from the CNS to skeletal muscle causing it to contract

Sensory neurones (afferent neurones) take nerve impulses from sensory receptors into the CNS

Relay (or sometimes Inter) neurones are found within the CNS and basically link sensory to motor neurones.

These three types of neurone also have different structures although many features are shared….


This is a diagram of a generalised motor neurone:  I know it is a motor neurone since the cell body is at one end of the cell.  The cell body contains the nucleus, most of the cytoplasm and many organelles.  Structures that carry a nerve impulse towards the cell body are called dendrites (if there are lots of them) and a dendron if there is only one.  The axon is the long thin projection of the cell that takes the nerve impulse away from the cell body.  The axon will finish with a collection of nerve endings or synapses.


Neurones can only send nerve impulses in one direction.  In the diagram above these two cells can only send impulses from left to right as shown.  This is due to the nature of the junction between the cells, the synapse (see later on….)


The diagram above shows a sensory neurone.  You can tell this because it has receptors at one end collecting sensory information to take to the CNS.  The position of the cell body is also different in sensory neurones:  in all sensory neurones the  cell body is off at right angles to the axon/dendron.

You can see from the diagrams that motor and sensory neurones tend to be surrounded by a myelin sheath.  Myelin is a type of lipid that acts as an insulator, speeding up the nerve impulse from around 0.5m/s in unmyelinated neurones to about 100 m/s in the fastest myelinated ones.  The myelin sheath is made from a whole load of cells (glial cells) but there are gaps between glial cells called nodes of Ranvier.  These will become important in Y12/13 when you study how the impulse manages to travel so fast in a myelinated neurone.

Relay neurones, also known as interneurones, have a much simpler structure.  They are only found in the CNS, almost always unmyelinated and have their cell body in the centre of the cell.


The diagram above shows the three types of neurone and indeed how they are linked up in a simple reflex arc.  The artist hasn’t really shown the interneurone structure very well, but it was the best I could find just now…..

Nerve cells are linked together (and indeed linked to muscle cells) by structures known as synapses.  There are a lot of synapses in your nervous system.  The human brain contains around 100 billion neurones and each neurone is linked by synapses to around 1000 other cells:  a grand total of 100 trillion synapses. 100 000 000 000 000 is a big number.

Synapse chemical synapse

The big idea with synapses is that the two neurones do not actually touch. There is a tiny gap called the synaptic cleft between the cells.  The nerve impulse does not cross this tiny gap as an electrical event but instead there are chemicals called neurotransmitters that diffuse across the synaptic cleft.

The nerve impulse arrives at the axon terminal of the presynaptic neurone.  Inside this swelling are thousands of tiny membrane packets called vesicles, each one packed with a million or so molecules of neurotransmitter.  When the impulse arrives at the terminal, a few hundred of these vesicles are stimulated to move towards and then fuse with the cell membrane, releasing the neurotransmitter into the synaptic cleft.  The neurotransmitter will diffuse rapidly across the gap and when it reaches the post-synaptic membrane, it binds to specific receptor molecules embedded in the post-synaptic membrane.  The binding of the neurotransmitter to the receptor often causes a new nerve impulse to form in the post-synaptic cell.

These chemical synapses are really beautiful things.  They ensure the nerve impulse can only cross the synapse in one direction (can you see why?) and also they are infinitely flexible.  They can be strengthened and weakened, their effects can be added together and when this is all put together, complex behaviour can emerge.  I am going to exhibit some complex behaviour now by choosing to take my dogs for a walk… And it all happened due to synapses in my brain!



  1. kleineslebenszeichen

    Dear Mr. Gillam
    I am currently writing my MD thesis on synaptic cell adhesion molecules. Figure 2 of this post is really helpful for understanding synaptic transmission and I would love to use it for my introduction. My thesis including this figure would not be printed in an official journal but would be made publicly available as a print version at Freiburg university after my thesis defense this fall. I would be happy if I was allowed to use it.

    I hope to hear from you soon.

    R. Wicklein

  2. beccawklein

    Dear Mr. Gillam
    I am currently writing my MD thesis on synaptic cell adhesion molecules. Figure 2 in this post is really helpful for the understanding of synaptic transmission and I would love to use it for my introduction. My thesis including this figure would not be printed in an official journal but would be made publicly available after my defense. I would be happy if I was allowed to use it.

    I hope to hear from you soon.

    R. Wicklein

    • Paul Gillam

      Hi Rebecca, I am afraid I cannot really help you as all the images on my wordpress site are taken from a Google Search and so I do not have any authority to permit their use elsewhere. I am sorry not to be of more help but I do not have any copyright for any of my images I am afraid.

  3. Pingback: Comparing Nervous and Hormonal Coordination: Grade 9 Understanding for IGCSE Biology 2.86 | PMG Biology
  4. Notbrian

    Hi Im not sure if youre still answering questions but how do drugs like heroin and alcohol work? They are depressants yet they stimulate good feelings in us. How does that work?

    By the way I really appreciate this site- it’s clear that you understand exactly what we need to and dont need to know for the exams (other sites often go off topic or don’t give enough detail)

    • Paul Gillam

      Thanks for your kind comments – much appreciated.

      Heroin is a drug derived from the opium poppy and binds to receptors in your brain called opioid receptors. It is a powerful painkiller and in small doses can cause a feeling of warmth and wellbeing. This website explains it quite well:

      Alcohol’s mechanism of action is even harder to explain. Although the drug is a depressant, in small doses it can help people overcome social inhibitions and give a feeling of happiness. It works through influencing the concentrations of an important neurotransmitter in the brain called GABA. Alcohol binds to GABA receptors on neurones in the brain, lowering the activity of the nerve cells. So alcohol will slow down reaction times and make driving dangerous.

  5. chameleonsoul249

    I still dont get why the impulses move in one direction only. Is it because the neurotransmitters released fit into specific receptors at the post synaptic nerve ending of the fibre? Please explain this

    • Paul Gillam

      This is a good question and not that easy to explain in a few characters. There are two parts to my answer….

      1) Within a single nerve cell the impulse can only travel in one direction. This is due to a property of the nerve impulse called a refractory period. Basically this means that the part of the cell that the impulse has just passed through can’t itself be stimulated to generate a new impulse. So the impulse can’t turn round within a cell….

      2) The junctions between nerve cells are called synapses. These can only transmit an impulse from cell to cell in one direction. The pre-synaptic cell is the only cell that releases neurotransmitter, the post-synaptic cell is the only one that has receptors for neurotransmitter.

      Hope this help……

      • chameleonsoul249

        It did, the second point makes more sense to me. Thank you, I’ll be asking more questions if that’s okay, but before answering, please let me know if it’s within the syllabus or not

  6. Angad Singh

    This is REALLY great. Alll of this is part of the 2016 IGCSE syllabus ( I live in India) and its really great to have all of this compiled by a teacher from Eton.

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